DOĞRU EGZERSİZİN YARARLARI HAKINDA HER GEÇEN GÜN YENİ YAYINLANAN BİLİMSEL YAYINLARLA KARŞILAŞIYORUZ.
SON YAPILAN ÇALIŞMADA EGZERSİZİN MEME KANSERİNDE Kİ YARALARI İLE İLGİLİ YAPILMIŞ.
ÇALIŞMAYA 479 METASTAZI OLMAYAN MEME KANSERİ HASTASI ALINMIŞ
HASTALARA 6 HAFTA BOYUNCA KEMOTERAPİ İLE BERABER, AEROBİK YÜRÜME VE AĞIRLIĞA KARŞI DİRENÇ UYGULAMA EGZERSİZLERİ ÖNERİLMİŞ.
EGZERSİZ PROGRAMI ÖNCESİ VE SONRASI HASTALARIN YAŞAM KALİTESİ VE KANDA İNFLAMATUAR BAZI MARKIRLARIN DÜZEYİ BAKILMIŞ VE KARŞILAŞTIRILMIŞ.
EGZERSİZ MEME KANSERİ HASTALARINDA İNFLAMSYONA NEDEN OLAN SİTOKİNLERİN SEVİYESİNİ DÜZELTİYOR VE KOGNİTİF FALİYETLERİ DÜZELTEREK YAŞAM KALİTESİNİ ARTIRIYOR
ÇALIŞMADA, PROİNFLAMATUAR SİTOKİNLER OLAN IFNg, IL-8, IL-1b DÜZEYİNDE AZALMA VE ANTİ İNFLAMATUAR SİTOKİN OLAN IL-6, IL-10, sTNFra DÜZEYİNDE ARTMA EGZERSİZ PROGRAMI SONRASI TESPİT EDİLMİŞ.
SONUÇ OLARAK, UYGUN EGZERSİZ PROGRAMINA DAHİL OLAN KEMOTERAPİ ALAN KADIN HASTALARIN YAŞAM KALİTESİNDE DÜZELME VE İNFLAMASYONA NEDEN OLAN SİTOKİNLRDE BELİRGİN DÜŞME SAPTANMIŞTIR.
________________________________________
KAYNAK:
EXCAP exercise effects on cognitive impairment and inflammation: A URCC NCORP RCT in 479 cancer patients.
Meeting:
J Clin Oncol 33, 2015 (suppl; abstr 9504)
Author(s):
Karen Michelle Mustian, Michelle Christine Janelsins, Luke Joseph Peppone, Charles Stewart Kamen, Joseph John Guido, Charles E. Heckler; University of Rochester Medical Center, Rochester, NY; Department of Surgery, University of Rochester Medical Center, Rochester, NY
Background: Cognitive impairment (CI) is one of the most troublesome side effects experienced by patients, arises due to chronic inflammation, and impairs quality of life (QOL). We conducted a nationwide, multi-site, phase III RCT examining the efficacy of exercise for improving CI and inflammation through the URCC NCORP Research Base. Methods: Non-metastatic cancer patients receiving chemotherapy were randomized into 2 arms: 1) chemotherapy and 2) chemotherapy plus a 6-week (wk) exercise intervention–Exercise for Cancer Patients (EXCAP): a home-based, personalized prescription of aerobic walking and anaerobic resistance band training. CI and inflammation were assessed via the FACT-Cog and standard serum Luminex assays, respectively, at pre- and post-intervention. Results: 479 patients beginning chemotherapy were accrued (94% female, 84% breast cancer, mean age = 54). ANCOVAs controlling for baseline CI and chemotherapy cycle (1 wk, 2 wk, 3 wk) revealed significant differences in CI total score, perceived CI, impact of CI on QOL, and perceived CI by others (all p 0.05) with a trend for differences in perceived cognitive ability (p 0.10) between groups at post-intervention. Follow-up analyses showedexercise participants receiving 2 wk cycles of chemotherapy demonstrated less CI overall and across all domains (all p 0.05) except perceived cognitive ability (p 0.10) than controls at post-intervention. Ttests revealed an exercise-induced anti-inflammatory response with down-regulation of pro-inflamatory cytokines (IFNg, IL-8, IL-1b) and up-regulation of anti-inflammatory cytokines (IL-6, IL-10, sTNFra) in exercisers (all p 0.05). Conversely, t-tests revealed down-regulation of IL-10 and less up-regulation of sTNFra in controls (all p 0.05). Canonical correlations revealed a trend where changes in inflammation predicted changes in CI in exercises (r = 0.33; p = .06), but not control. Conclusions: EXCAP exercise improves CI and inflammation in patients receiving chemotherapy, and exercise-induced anti-inflammatory responses may elicit improvements in CI. Clinicians should consider prescribing EXCAP to reduce CI ad inflammation. NCI UGCA189961 & K07CA120025. Clinical trial information: NCT00924651
